- Carinol Quality - repartition body composition - prevent fat accumulation in fat cells - valuable in both mass gaining and fat loss phase CLA has repeatedly to be shown as a great body partitioning agent in animal studies. It is also added to feeding to improve growth efficiency in farm animals. Recent research studied CLA in greater details in its applications for humans. There are 2 types of CLA molecules the 9,11 CLA isomer are found to improve muscle growth. CLA 9,11 isomer appears to be a product our body can make in small quantity as a "natural" factor in growth in resistance-training hypertrophy. The other 10,12 CLA isomer affects fat accumulation in the body. Our body is not able to synthesize 10,12 CLA isomer, its intake from dietary intake (e.g. beef, dairy) especially important. 10,12 CLA isomer do not possess lipolytic (fat burning) effects. This molecule primarily prevents lipogenesis (fat cells filling), which is consistent with the results, growing rats taking CLA supplements don’ t become as fat as those taking placebo. This is because rat's fat cells don’t seem to enlarge when they are taking 10, 12 CLA isomer. Without 10,12 CLA isomers rats normally grow larger and fatter with age. The 10,12 isomer seems to prevent this undesirable symptom of aging. 10,12 CLA isomer is an inhibitor of lipoprotein lipase (LPL), an enzyme that move bloodstream fat into fat cells. It is also an inhibitor of delta-9 desaturase an enzyme that increase the rate of body fat making from excess calories. This 2 properties made CLA an excellent body partitioning agent to gear the body towards increase leaness. On a low fat diet It may be valuable in the "mass gaining phase," to reduce fat gain that always come with muscle gain in a natural athletes. Research suggest 3.4g per day dose might improve feed efficiency (more tissue gain at a given amount of food) without fat gain in college weight trainers. Scientific References 1. First International Conference on Conjugated Linoleic Acid. June 10-13, 2001; Aalesund, Norway. 2. Lowery, L. et al. (1998). Conjugated linoleic acid enhances muscle size and strength gains in novice bodybuilders. Med Sci Sports Exerc. (Suppl) 230 (5): S182. 3. Biosci Biotechnol Biochem. 2005 Dec;69(12):2409-15. Combined Effects of Dietary Protein Type and Fat Level on the Body Fat-Reducing Activity of Conjugated Linoleic Acid (CLA) in Rats. Akahoshi A et al. 4. J Nutr. 2005 May;135(5):1124-30. The combination of dietary conjugated linoleic acid and treadmill exercise lowers gain in body fat mass and enhances lean body mass in high fat-fed male Balb/C mice. Bhattacharya A et al. 5. J Nutr. 2005 Apr;135(4):778-84. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, Gudmundsen O. 6. J Nutr. 2000 Dec;130(12):2943-8. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O. 7. Int J Obes Relat Metab Disord. 2001 Aug;25(8):1129-35. Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial. Riserus U, Berglund L, Vessby B. 8. Food Chem Toxicol. 2004 Oct;42(10):1701-9. Safety profile of conjugated linoleic acid in a 12-month trial in obese humans. Whigham LD, O'Shea M, Mohede IC, Walaski HP, Atkinson RL. 9. J Int Med Res. 2001 Sep-Oct;29(5):392-6. Erratum in: J Int Med Res 2002 Mar-Apr;30(2):210. Correction of dosage error in abstract. Conjugated linoleic acid reduces body fat in healthy exercising humans. Thom E, Wadstein J, Gudmundsen O. 10. Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E98-E105. Epub 2003 Mar 4. Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat. Henriksen EJ et al. 11. Br J Nutr. 1999 Oct;82(4):309-17. Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. de Deckere EA et al. 12. Lipids. 2003 May;38(5):497-504. Trans-10,cis-12 CLA increases liver and decreases adipose tissue lipids in mice: possible roles of specific lipid metabolism genes.Warren JM et al. 13. Lipids. 2004 Feb;39(2):135-41. Contrasting effects of t10,c12- and c9,t11-conjugated linoleic acid isomers on the fatty acid profiles of mouse liver lipids. Kelley DS et al. |
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