- Buffer acid building-up in muscles to boost performance in anaerobic performance - Chelation of reactive metals ions - Powerful protector against harmful modification of body proteins - Protect non-replaceable body cells like muscles, nerve and brain cells against aging Non replaceable body tissues like nerve cells (neurons) and muscle cells (myocytes) are high in Carnosine to protect them from destruction. Muscle levels of Carnosine correlate well with the maximum life spans of animal types. Carnosine is like a "designer" cell protector evolved from human's high meat intake. 100g of cooked beef contains about 124mg of Carnosine, hence it takes about 1.2kg of cooked beef to give 1.5g of Carnosine. Carnosine protects our cells from abnormal protein carbonylation (glycation) very effectively. When lab-animals are supplemented with Carnosine, markers of glycation like AGEs (advanced glycation end products) are well-inhibited. AGEs physically alter proteins, DNA and lipids and hence their proper functioning to cause a disruption in signalling within the body. Some research have also pointed out agents that specifically chelate copper and zinc ions but preserve Magnesium and Calcium may be of therapeutic value in certain diseases of the nervous system. Copper and zinc are released during normal synaptic activity. However, in the presence of a mildly acidic environment which is a characteristic of Alzheimer's disease, they reduce to their ionic forms and become toxic to the nervous system. Research has shown that carnosine can buffer copper and zinc toxicity in the brain. Carnosine (Beta-Alanyl-L-Histidine) is formed by joining amino acids Alanine and Histidine. With beta alanine being touted as a hot supplement for bodybuilding, it is necessary to point out that Alanine needs to be joined up with Histidine to form Carnosine to exert its muscle pH-buffering effect. Carnosine is the end product that provides the full benefits. Take alanine and histidine to get the effect of Carnosine (a dipeptide making up of 2 amino acids joined together) will be like taking Arginine, Methionine and Glycine to get the benefit of Creatine (a tripeptide making up of 3 amino acids joined together). A much less effective way. Extensive animal and human studies have demonstrated that dipeptides and tripeptides like Carnosine and Creatine can be absorbed intact into the blood streams and made their entry into body tissues to exert their benefits. Hence, it made lots of sense to consume Carnosine rather than Alanine and Histidine. One will need to consume 1.2kg of red meat to get 1500mg of Carnosine. The bioavaliability of Carnosine is a good 65% from food and estimated to be 80-90% when consume on an empty stomach. A good dosage for those who want to benefit from Carnosine supplementation will be 3-6 caps per day. Based on the scientific data, the saturation principle for Creatine supplementation applies to Carnosine as well. Hence the benefits build up with continuous time of regular ingestion till saturation occurs to give the maximum benefits. Scientific References 1. J Nutr Sci Vitaminol (Tokyo). 1976;22(2):147-57. Intestinal absorption of beta-alanine, anserine and carnosine in rats. Hama T et al. 2. J Strength Cond Res. 2005 Nov;19(4):725-9. The carnosine content of vastus lateralis is elevated in resistance-trained bodybuilders. Tallon MJ et al. 3. Amino Acids. 2006 Sep 5; Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion. Zoeller RF et al. 4. Biochemistry (Mosc). 2000 Jul;65(7):866-8. Carnosine as a potential anti-senescence drug. Gallant S, Semyonova M, Yuneva M. 5. Biosci Rep. 1999 Dec;19(6):581-7. Carnosine, the protective, anti-aging peptide. Boldyrev AA, Gallant SC, Sukhich GT. 6. Bull Exp Biol Med. 2003 Feb;135(2):130-2. Protective effect of carnosine on Cu,Zn-superoxide dismutase during impaired oxidative metabolism in the brain in vivo. Stvolinskii SL et al. 7. Amino Acids. 2006 May;30(3):279-89. Epub 2006 Mar 24. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Harris RC et al. 8. Amino Acids. 2006 Jul 28; Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Hill CA et al. 9. Amino Acids. 2006 Nov 30; Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Stout JR et . al. 10. J Nutr. 2007 Mar;137(3):589-93. Carnosine concentration of ingested meat affects carnosine net release into the portal vein of minipigs. Bauchart C et al. 11. J Agric Food Chem. 2005 Jun 15;53(12):4736-9. Quantitation of carnosine in humans plasma after dietary consumption of beef. Park YJ, Volpe SL, Decker EA. 12. Jpn J Physiol. 2002 Apr;52(2):199-205. High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprinting.Suzuki Y. |
Supplement Facts
Serving size: 1 Capsule
Servings Per Container: 90
Amount Per Serving
L-Carnosine 500mg
(alanylhistidine)
Other Ingredients: Rice powder, magnesium
stearate and silicon dioxide. Capsule
consists of gelatin.
Serving size: 1 Capsule
Servings Per Container: 90
Amount Per Serving
L-Carnosine 500mg
(alanylhistidine)
Other Ingredients: Rice powder, magnesium
stearate and silicon dioxide. Capsule
consists of gelatin.
| Jarrow's Formula's L-Carnosine 90 Caps 500mg per Cap Introductory Price: $59 |
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