- Promote muscles relaxation - Enhance rest naturally - Improve sleep quality - Speed up the CNS recovery Valerian is a plant native to North America and Europe. Its roots are used medically. Valerian roots demonstrates a number of pharmacological effects, including normalization of the central nervous system (as an adaptogen, a sedative in states of agitation and a stimulant in cases of extreme fatigue), lowering of blood pressure, enhancement of the flow of bile, relaxation of intestinal musclesa , antitumor and antibiotic activity. Valerian should be taken 30-45mins before retiring. 2g (4 caps) is needed per dose to give good effect. Both compounds in Valerian, namely valepotriates and valeric acids are capable of binding to same brain receptors as many mental drugs. However, it did not appear to have sides effects like impaired brain function, morning hangover and dependency. Insufficent sleep is associated with decresed leptin levels, increase ghrelin levels and increased hunger and appetite Valerian should be taken with meals to maximise absorption of the active ingredients in them. Scientific Reference 1. J Pharm Dyn 4, 612-623, 1981. Pharmacological studies on iridoid compounds. III. The choleretic mechanism of iridioid compounds. Takeda S, Endo T, and Aburada M. 2. Planta Medica 42, 62-68, 1981. Pharmacological screening of valerenal and some other components of essential oil of Valeriana officinalis. Hendriks H, et al.. 3. Ann Intern Med. 2004 Dec7;141(11)846-50. Brief communication. Sleep curtilment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Spiegel K, Tasali E, Penev P, Van Cauter E. 4. PLoS Med. 2004 Dec;1(3):e62. Epub 2004 Dec 7. Short Sleep Duration is associated with reduced Leptin, Elevated Ghrelin, and increased Body Mass Index. Taheri S, Lin L, Austin D, Young T, Mignot E. 5. Phytomedicine. 2004 Nov;11(7-8):633-8. In vitro binding experiments with a Valerian, hops and their fixed combination extract (Ze91019) to selected central nervous system receptors. Abourashed EA, Koetter U, Brattstrom A. 6. Pharmacopsychiatry. 2000 Mar;33(2):47-53. Critical evaluation of the effect of valerian extract on sleep structure and sleep quality. Donath F, Quispe S, Diefenbach K, Maurer A, Fietze I, Roots I. 7. Pharmacol Biochem Behav. 1989 Apr;32(4):1065-6. Double blind study of a valerian preparation. Lindahl O, Lindwall L. |
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